Curcumin Attenuates Lipopolysaccharide-Induced Neuroinflammation and Memory Deficiency by Inhibiting Microglia Activation in Mice Hippocampus

Background. Curcumin has a variety of properties, including antioxidant and anti-inflammatory ones, demonstrated some protective prospects on neurological conditions.
 Aim: This study explored the neuroprotective ability curcumin in lipopolysaccharide-induced neuroinflammation an animal model.
 Methods. A total thirty-two adult male mice were randomly assigned to four groups (A, B, C, D, n=8): Group (Control) received distilled water; B was administered lipopolysaccharide (LPS) only induce for seven days; C treated with both LPS simultaneously fourteen D days. After appropriate exposure mice, their cognitive abilities assessed using Y-maze novel object recognition tests. At termination administration period, sacrificed, hippocampi dissected histology immunostaining GFAP Iba1. Statistical analysis data generated done GraphPad prism. Tests significance one-way ANOVA Tukey tests post-hoc.
 Results. significantly (p < 0.05) increased recognition, mean alternation, markedly restored neuronal distortion caused by toxicity CA3 region dentate gyrus hippocampus animals as compared B. In addition, down-regulated Iba1 expression cell activities gyrus.
 Conclusions. showed promising role attenuating LPS-induced brain inhibiting microglial activation improving memory neurotoxic mice.